Variant interpretation, with evidence in view.
Browse variant classifications with their recorded evidence and expert-panel criteria.
Search HGVS or explore the archive.
Start with an HGVS variant
Browse variants
Every interpretation in the database is free to read — no account needed. A free account adds 5 new interpretations a day, up to 10 a week.
Create accountExplore by gene
Every gene in the HERA database, by classification mix.
How an interpretation is assembled
The workflow records variant evidence, criterion assessments and the applicable classification framework for review.
Normalise
The HGVS string is validated and mapped to genomic coordinates on both GRCh37 and GRCh38. Versionless accessions are rejected here.
Gather evidence
Population frequency, splicing predictions, in-silico scores, ClinVar submissions, somatic databases, and the literature for the gene.
Apply the right spec
When a relevant ClinGen VCEP specification is available, its criterion-specific rules govern the assessment.
Combine
Recorded criteria are evaluated against the applicable combination rules. The report preserves the final call and supporting rationale.