Project HERA
Variant repository
Browse completed HERA interpretations, including applied criteria and available source records. No account is required to read reports.
Browse by gene
Ordered by number of pathogenic calls, then by volume.
PTEN
BRCA2
TP53
ATM
BRCA1
PALB2
MLH1
TET2
NRAS
PTPN11
MSH6
MSH2
BRAF
KRAS
RUNX1
EGFR
POLE
NF1
SMARCA4
BARD1
STK11
DNMT3A
RB1
RET
FH
FLT3
FBXW7
GNAQ
APC
CDKN2A
CTNNB1
TSC1
PPM1D
IDH2
NF2
HRAS
ATRX
SMAD4
GNA11
SETD2
ARID1A
IDH1
PIK3CA
POLD1
DICER1
MUTYH
SF3B1
RAD51C
RAD51D
PIK3R1
ESR1
NOTCH3
FGFR1
ZRSR2
KIT
CBL
ERBB2
BCOR
EZH2
GBA1
SMARCB1
FGFR3
GNAS
PMS2
CHEK2
TSC2
MBD4
PTCH1
MSH3
NTRK1
MLH3
ROS1
MET
CDK4
BAP1
CDK12
VHL
CREBBP
FGFR2
EIF1AX
PHF6
CUX1
GALNT12
ATR
FANCD2
AR
DDX41
ASXL1
NOTCH2
NOTCH1
RNF43
NTRK2
ETV6
CYP21A2
PDGFRA
MDM2
RAD50
FOXL2
STAG2
FGF3
MPL
LRRK2
NTHL1
FLCN
ABL1
RECQL4
AKT1
PPP2R1A
U2AF1
SMO
CEBPA
NBN
PRKN
FBXO31
FBP1
MAX
MYD88
JAK2
SLC12A3
TERT
PRPF8
BRIP1
AXIN2
RAD51B
EZHIP
MYC
KMT2A
CDH1
BCORL1
KEAP1
CHEK1
FANCL
CDK6
MYCN
SDHB
SETBP1
KLLN
CTNNA1
CCND1
FGFR4
SH2B3
GATA2
MEN1
EPCAM
SDHA
LZTR1
BMPR1A
ALK
MYCL
ERBB3
DDR2
NTRK3
SLX4
PPARG
KDR
MAP2K1
HTRA1
B3GALT6
MITF
NFE2L2
H3C2
CDKN2B
SLC2A2
CCNE1
PRKD1
CDC73
MRE11
FANCA
FANCI
RAD54L
MYH7
TARDBP
ANKRD26
WT1
RAF1
MAP2K2
LPL
CREB3L3
AIP
VPS13C
SPG11
SRSF2
HOXB13
POLG
COL4A1
CDK2
ERBB4
STAT3
MDM4
MAPK1
POT1
HNF1A
CCND2
CFTR
RICTOR
PKD1
PSEN1
JAK3
JAK1
GLA
PIK3CB
KMT2B
RAD51
PDCD10
MAP2K4
CACNA1C
DMP1
RPS20
H3-3A
DNAH11
ERCC2
MTOR
EGFL7
MDC1
SOX17
MYOC
TAF1
SDHD
CALR
RAD21
COL4A2
GJB2
DLST
Recently interpreted
Newest first across every gene. Pick a gene above to narrow the list.
Variant
Protein change
Classification
POLD1
NM_001308632.1:c.845C>T
NP_001295561.1:p.(T282M)
VUS
View →
NF1
NM_000267.3:c.3118A>T
NP_000258.1:p.(K1040*)
Likely Pathogenic
View →
NF1
NM_001042492.2:c.3479G>A
NP_001035957.1:p.(G1160D)
VUS
View →
RB1
NM_000321.2:c.2236G>T
NP_000312.2:p.(E746*)
VUS
View →
NOTCH3
NM_000435.2:c.5946G>T
NP_000426.2:p.(E1982D)
VUS
View →
NOTCH1
NM_017617.5:c.5081A>G
NP_060087.3:p.(Q1694R)
VUS
View →
BRCA2
NM_000059.4:c.*23A>C
NP_000050.3:p.?
VUS
View →
PALB2
NM_024675.4:c.1096A>G
NP_078951.2:p.(N366D)
VUS
View →
MSH3
NM_002439.5:c.2800G>T
NP_002430.3:p.(G934C)
VUS
View →
PTEN
NM_000314.8:c.951_952del
NP_000305.3:p.(L318Yfs*6)
Likely Pathogenic
View →
BRCA2
NM_000059.4:c.4284dup
NP_000050.3:p.(Q1429Sfs*9)
Pathogenic
View →
BRIP1
NM_032043.3:c.143C>A
NP_114432.2:p.(T48K)
VUS
View →
NBN
NM_002485.4:c.1873G>T
NP_002476.2:p.(E625*)
VUS
View →
MLH1
NM_000249.4:c.1039-25T>A
NP_000240.1:p.?
Benign
View →
MLH1
NM_000249.4:c.1344G>T
NP_000240.1:p.(E448D)
VUS
View →
BARD1
NM_000465.4:c.1409A>G
NP_000456.2:p.(N470S)
VUS
View →
MLH1
NM_000249.4:c.1989G>A
NP_000240.1:p.(E663=)
Pathogenic
View →
MLH1
NM_000249.4:c.381-1G>A
NP_000240.1:p.?
Pathogenic
View →
NRAS
NM_002524.5:c.38G>T
NP_002515.1:p.(G13V)
VUS
View →
ATR
NM_001184.3:c.2112G>T
NP_001175.2:p.(K704N)
VUS
View →
MTOR
NM_004958.4:c.3610A>G
NP_004949.1:p.(I1204V)
VUS
View →
MSH6
NM_000179.2:c.4068_4071dup
NP_000170.1:p.(K1358Dfs*2)
Benign
View →
CREBBP
NM_004380.2:c.3215C>G
NP_004371.2:p.(S1072C)
VUS
View →
FGFR3
NM_000142.4:c.109+2T>C
NP_000133.1:p.?
Likely Pathogenic
View →
NTRK1
NM_002529.3:c.375C>A
NP_002520.2:p.(N125K)
VUS
View →
ZRSR2
NM_005089.3:c.758T>C
NP_005080.1:p.(V253A)
VUS
View →
STAG2
NM_001042749.1:c.488T>A
NP_001036214.1:p.(M163K)
VUS
View →
RUNX1
NM_001754.4:c.1270T>G
NP_001745.2:p.(S424A)
Benign
View →
RUNX1
NM_001754.4:c.1265A>C
NP_001745.2:p.(E422A)
Benign
View →
STAG2
NM_001042749.1:c.482T>A
NP_001036214.1:p.(L161H)
VUS
View →
RUNX1
NM_001754.4:c.1252A>T
NP_001745.2:p.(M418L)
Benign
View →
NF1
NM_000267.3:c.2355A>G
NP_000258.1:p.(E785=)
VUS
View →
FBXW7
NM_033632.3:c.1394G>A
NP_361014.1:p.(R465H)
Likely Pathogenic
View →
PPP2R1A
NM_014225.5:c.536C>G
NP_055040.2:p.(P179R)
Likely Pathogenic
View →
DICER1
NM_177438.2:c.1708A>T
NP_803187.1:p.(K570*)
Likely Pathogenic
View →
GNA11
NM_002067.5:c.892C>T
NP_002058.2:p.(P298S)
VUS
View →
VHL
NM_000551.3:c.434A>T
NP_000542.1:p.(Q145L)
VUS
View →
NRAS
NM_002524.5:c.101C>T
NP_002515.1:p.(P34L)
VUS
View →
TSC1
NM_000368.4:c.682C>T
NP_000359.1:p.(R228*)
Pathogenic
View →
SMARCA4
NM_001128849.1:c.3484G>A
NP_001122321.1:p.(G1162S)
Likely Pathogenic
View →
APC
NM_001127511.3:c.3865del
NP_001120983.2:p.(I1289*)
Likely Pathogenic
View →
SMARCB1
NM_003073.4:c.1091_1093del
NP_003064.2:p.(K364del)
Not classified
View →
HRAS
NM_001130442.2:c.374T>C
NP_001123914.1:p.(V125A)
VUS
View →
SMARCA4
NM_001128849.1:c.4927G>T
NP_001122321.1:p.(G1643C)
VUS
View →
SMARCB1
NM_003073.4:c.1130G>A
NP_003064.2:p.(R377H)
Pathogenic
View →
ATR
NM_001184.3:c.6680A>G
NP_001175.2:p.(N2227S)
VUS
View →
EIF1AX
NM_001412.4:c.338-1G>C
NP_001403.1:p.?
Likely Pathogenic
View →
GNAS
NM_000516.5:c.601C>T
NP_000507.1:p.(R201C)
Likely Pathogenic
View →
CDK12
NM_016507.4:c.2964C>T
NP_057591.2:p.(F988=)
Likely Benign
View →
TERT
NM_198253.2:c.899G>A
NP_937983.2:p.(G300D)
VUS
View →
EGFR
NM_005228.4:c.2237_2255delinsT
NP_005219.2:p.(E746_S752delinsV)
Likely Pathogenic
View →
TERT
NM_198253.2:c.833C>T
NP_937983.2:p.(P278L)
VUS
View →
ERCC2
NM_000400.3:c.298G>C
NP_000391.1:p.(E100Q)
VUS
View →
CHEK2
NM_007194.4:c.176C>A
NP_009125.1:p.(T59K)
VUS
View →
PTPN11
NM_002834.4:c.179G>T
NP_002825.3:p.(G60V)
Likely Pathogenic
View →
FLT3
NM_004119.2:c.2246C>A
NP_004110.2:p.(S749*)
VUS
View →
EIF1AX
NM_001412.4:c.25G>C
NP_001403.1:p.(G9R)
VUS
View →
RB1
NM_000321.2:c.2341C>T
NP_000312.2:p.(P781S)
VUS
View →
MYH7
NM_000257.3:c.2548G>A
NP_000248.2:p.(A850T)
VUS
View →
PTPN11
NM_002834.4:c.169C>A
NP_002825.3:p.(Q57K)
VUS
View →
RAD51B
NM_133509.4:c.263C>G
NP_598193.2:p.(S88C)
VUS
View →
SF3B1
NM_012433.3:c.2098A>G
NP_036565.2:p.(K700E)
Likely Pathogenic
View →
SETD2
NM_014159.6:c.7572dup
NP_054878.5:p.(K2525*)
VUS
View →
FGFR4
NM_213647.2:c.1144G>T
NP_998812.1:p.(V382L)
VUS
View →
FGF3
NM_005247.2:c.121G>T
NP_005238.1:p.(G41W)
VUS
View →
VHL
NM_000551.3:c.241C>T
NP_000542.1:p.(P81S)
Benign
View →
BARD1
NM_000465.4:c.221G>T
NP_000456.2:p.(C74F)
VUS
View →
ATR
NM_001184.3:c.1751A>G
NP_001175.2:p.(D584G)
VUS
View →
HRAS
NM_005343.4:c.182A>G
NP_005334.1:p.(Q61R)
Pathogenic
View →
NTRK3
NM_001012338.2:c.1730C>T
NP_001012338.1:p.(P577L)
VUS
View →
BRAF
NM_004333.5:c.2107G>A
NP_004324.2:p.(E703K)
VUS
View →
CTNNB1
NM_001098209.2:c.98C>A
NP_001091679.1:p.(S33Y)
Pathogenic
View →
DICER1
NM_177438.2:c.1468C>T
NP_803187.1:p.(R490C)
VUS
View →
POLD1
NM_002691.4:c.2716_2717del
NP_002682.2:p.(R906Dfs*47)
VUS
View →
MLH1
NM_000249.3:c.1433A>G
NP_000240.1:p.(D478G)
VUS
View →
ATM
NM_000051.4:c.4574T>C
NP_000042.3:p.(I1525T)
VUS
View →
MSH2
NM_000251.3:c.1132del
NP_000242.1:p.(E378Kfs*34)
VUS
View →
KRAS
NM_033360.3:c.35_37delinsATT
NP_203524.1:p.(G12_G13delinsDC)
VUS
View →
ATM
NM_000051.3:c.4110_4111delinsAA
NP_000042.3:p.(D1371N)
VUS
View →
BARD1
NM_000465.4:c.1788del
NP_000456.2:p.(K596Nfs*9)
Pathogenic
View →
EGFR
NM_005228.4:c.2314_2319dup
NP_005219.2:p.(P772_H773dup)
VUS
View →
AR
NM_000044.4:c.515C>T
NP_000035.2:p.(P172L)
VUS
View →
NOTCH2
NM_024408.3:c.7354C>T
NP_077719.2:p.(Q2452*)
VUS
View →
RAD54L
NM_003579.4:c.888C>T
NP_003570.2:p.(D296=)
Likely Benign
View →
STK11
NM_000455.5:c.249G>A
NP_000446.1:p.(K83=)
Likely Benign
View →
PMS2
NM_000535.7:c.86G>C
NP_000526.2:p.(G29A)
VUS
View →
BRCA2
NM_000059.4:c.8673_8674del
NP_000050.3:p.(R2892Tfs*14)
Pathogenic
View →
BRCA1
NM_007294.4:c.4935G>C
NP_009225.1:p.(R1645S)
Benign
View →
BRIP1
NM_032043.3:c.1794+19T>C
NP_114432.2:p.?
VUS
View →
STK11
NM_000455.5:c.*9G>A
NP_000446.1:p.?
VUS
View →
RAD51D
NM_002878.4:c.829C>G
NP_002869.3:p.(L277V)
VUS
View →
BRCA2
NM_000059.4:c.241T>C
NP_000050.3:p.(F81L)
Likely Benign
View →
CHEK1
NM_001274.5:c.922A>T
NP_001265.2:p.(S308C)
VUS
View →
BRCA1
NM_007294.4:c.1367T>C
NP_009225.1:p.(I456T)
Likely Benign
View →
MSH2
NM_000251.2:c.1381G>A
NP_000242.1:p.(D461N)
VUS
View →
BRAF
NM_004333.5:c.1447A>G
NP_004324.2:p.(K483E)
VUS
View →
ESR1
NM_001122740.1:c.1661G>A
NP_001116212.1:p.(S554N)
VUS
View →
BARD1
NM_000465.4:c.1694G>A
NP_000456.2:p.(R565H)
Likely Benign
View →
PTEN
NM_000314.8:c.106G>C
NP_000305.3:p.(G36R)
Pathogenic
View →
PIK3CA
NM_006218.4:c.2937-15T>C
NP_006209.2:p.?
VUS
View →