Project HERA
Variant repository
Browse completed HERA interpretations, including applied criteria and available source records. No account is required to read reports.
Browse by gene
Ordered by number of pathogenic calls, then by volume.
PTEN
BRCA2
TP53
ATM
BRCA1
PALB2
MLH1
TET2
NRAS
PTPN11
MSH6
MSH2
BRAF
KRAS
RUNX1
EGFR
POLE
NF1
SMARCA4
BARD1
STK11
DNMT3A
RB1
RET
FH
FLT3
FBXW7
GNAQ
APC
CDKN2A
CTNNB1
TSC1
PPM1D
IDH2
NF2
HRAS
ATRX
SMAD4
GNA11
SETD2
ARID1A
IDH1
PIK3CA
POLD1
DICER1
MUTYH
SF3B1
RAD51C
RAD51D
PIK3R1
ESR1
NOTCH3
FGFR1
ZRSR2
KIT
CBL
ERBB2
BCOR
EZH2
GBA1
SMARCB1
FGFR3
GNAS
PMS2
CHEK2
TSC2
MBD4
PTCH1
MSH3
NTRK1
MLH3
ROS1
MET
CDK4
BAP1
CDK12
VHL
CREBBP
FGFR2
EIF1AX
PHF6
CUX1
GALNT12
ATR
FANCD2
AR
DDX41
ASXL1
NOTCH2
NOTCH1
RNF43
NTRK2
ETV6
CYP21A2
PDGFRA
MDM2
RAD50
FOXL2
STAG2
FGF3
MPL
LRRK2
NTHL1
FLCN
ABL1
RECQL4
AKT1
PPP2R1A
U2AF1
SMO
CEBPA
NBN
PRKN
FBXO31
FBP1
MAX
MYD88
JAK2
SLC12A3
TERT
PRPF8
BRIP1
AXIN2
RAD51B
EZHIP
MYC
KMT2A
CDH1
BCORL1
KEAP1
CHEK1
FANCL
CDK6
MYCN
SDHB
SETBP1
KLLN
CTNNA1
CCND1
FGFR4
SH2B3
GATA2
MEN1
EPCAM
SDHA
LZTR1
BMPR1A
ALK
MYCL
ERBB3
DDR2
NTRK3
SLX4
PPARG
KDR
MAP2K1
HTRA1
B3GALT6
MITF
NFE2L2
H3C2
CDKN2B
SLC2A2
CCNE1
PRKD1
CDC73
MRE11
FANCA
FANCI
RAD54L
MYH7
TARDBP
ANKRD26
WT1
RAF1
MAP2K2
LPL
CREB3L3
AIP
VPS13C
SPG11
SRSF2
HOXB13
POLG
COL4A1
CDK2
ERBB4
STAT3
MDM4
MAPK1
POT1
HNF1A
CCND2
CFTR
RICTOR
PKD1
PSEN1
JAK3
JAK1
GLA
PIK3CB
KMT2B
RAD51
PDCD10
MAP2K4
CACNA1C
DMP1
RPS20
H3-3A
DNAH11
ERCC2
MTOR
EGFL7
MDC1
SOX17
MYOC
TAF1
SDHD
CALR
RAD21
COL4A2
GJB2
DLST
Recently interpreted
Newest first across every gene. Pick a gene above to narrow the list.
Variant
Protein change
Classification
CDK12
NM_016507.4:c.2351G>A
NP_057591.2:p.(R784Q)
VUS
View →
RNF43
NM_017763.5:c.1403C>T
NP_060233.3:p.(S468L)
VUS
View →
RAD51
NM_133487.3:c.235C>T
NP_597994.3:p.(R79C)
VUS
View →
FANCL
NM_018062.3:c.355G>A
NP_060532.2:p.(G119R)
VUS
View →
NF1
NM_001042492.2:c.6776T>C
NP_001035957.1:p.(V2259A)
VUS
View →
CDK6
NM_001259.8:c.915G>T
NP_001250.1:p.(R305S)
VUS
View →
CDK12
NM_016507.4:c.4099G>A
NP_057591.2:p.(V1367I)
VUS
View →
CCND1
NM_053056.3:c.517_519del
NP_444284.1:p.(E173del)
VUS
View →
RAD51C
NM_058216.3:c.848C>T
NP_478123.1:p.(T283I)
VUS
View →
MYC
NM_002467.6:c.1085C>T
NP_002458.2:p.(S362F)
Benign
View →
MBD4
NM_003925.3:c.1177T>G
NP_003916.1:p.(F393V)
Likely Benign
View →
BRIP1
NM_032043.3:c.476A>C
NP_114432.2:p.(K159T)
Likely Benign
View →
PPARG
NM_015869.4:c.338C>T
NP_056953.2:p.(P113L)
VUS
View →
RNF43
NM_017763.5:c.1196C>T
NP_060233.3:p.(P399L)
VUS
View →
RAD50
NM_005732.3:c.2301dup
NP_005723.2:p.(I768Hfs*14)
VUS
View →
FGFR3
NM_000142.4:c.1267G>A
NP_000133.1:p.(V423M)
VUS
View →
BARD1
NM_000465.4:c.1217G>A
NP_000456.2:p.(R406Q)
VUS
View →
NTRK2
NM_006180.4:c.2061C>A
NP_006171.2:p.(H687Q)
VUS
View →
FGFR1
NM_001174067.1:c.521C>G
NP_001167538.1:p.(T174R)
VUS
View →
CDKN2A
NM_000077.4:c.9_32del
NP_000068.1:p.(A4_P11del)
Not classified
View →
NF1
NM_000267.3:c.7039G>T
NP_000258.1:p.(E2347*)
Pathogenic
View →
ATRX
NM_000489.5:c.7315C>A
NP_000480.3:p.(P2439T)
Likely Benign
View →
BRAF
NM_004333.6:c.1741A>T
NP_004324.2:p.(N581Y)
VUS
View →
NOTCH2
NM_024408.3:c.3570G>C
NP_077719.2:p.(E1190D)
VUS
View →
TP53
NM_000546.5:c.214C>T
NP_000537.3:p.(P72S)
VUS
View →
TP53
NM_000546.5:c.214_215delinsTG
NP_000537.3:p.(P72C)
VUS
View →
POLE
NM_006231.3:c.4735C>T
NP_006222.2:p.(R1579C)
VUS
View →
ROS1
NM_002944.2:c.6079G>A
NP_002935.2:p.(E2027K)
VUS
View →
CYP21A2
NM_000500.9:c.1A>G
NP_000491.4:p.(M1?)
Pathogenic
View →
RAD51C
NM_058216.3:c.431T>C
NP_478123.1:p.(I144T)
VUS
View →
EIF1AX
NM_001412.4:c.44G>T
NP_001403.1:p.(G15V)
VUS
View →
RET
NM_020975.6:c.2776C>T
NP_066124.1:p.(H926Y)
VUS
View →
ATRX
NM_000489.5:c.5698-1G>C
NP_000480.3:p.?
Likely Pathogenic
View →
RAD51D
NM_002878.3:c.422T>C
NP_002869.3:p.(L141P)
VUS
View →
VHL
NM_000551.3:c.154G>A
NP_000542.1:p.(E52K)
Benign
View →
ROS1
NM_002944.2:c.6202_6203del
NP_002935.2:p.(V2068Lfs*15)
Likely Pathogenic
View →
—
VUS
View →
FGFR1
NM_001174067.1:c.2242C>T
NP_001167538.1:p.(H748Y)
VUS
View →
PIK3R1
NM_181523.2:c.2079A>T
NP_852664.1:p.(E693D)
VUS
View →
RAD51C
NM_058216.3:c.493A>G
NP_478123.1:p.(M165V)
VUS
View →
DICER1
NM_177438.2:c.4199A>G
NP_803187.1:p.(D1400G)
Likely Benign
View →
NRAS
NM_002524.4:c.35G>A
NP_002515.1:p.(G12D)
Likely Pathogenic
View →
KMT2B
NM_014727.2:c.5989C>G
NP_055542.1:p.(L1997V)
VUS
View →
SMARCA4
NM_001128849.1:c.1813-2A>T
NP_001122321.1:p.?
Likely Pathogenic
View →
STK11
NM_000455.5:c.129_141del
NP_000446.1:p.(K44Sfs*3)
Likely Pathogenic
View →
ROS1
NM_002944.2:c.6609C>A
NP_002935.2:p.(D2203E)
VUS
View →
NTRK2
NM_006180.4:c.2033C>T
NP_006171.2:p.(A678V)
VUS
View →
CBL
NM_005188.3:c.1240C>A
NP_005179.2:p.(Q414K)
VUS
View →
PIK3CB
NM_006219.2:c.3200A>T
NP_006210.1:p.(D1067V)
VUS
View →
TP53
NM_000546.6:c.-29+102T>G
NP_000537.3:p.?
VUS
View →
PTCH1
NM_000264.5:c.2438C>T
NP_000255.2:p.(P813L)
VUS
View →
BRCA1
NM_007294.3:c.5432A>G
NP_009225.1:p.(Q1811R)
VUS
View →
MYCN
NM_005378.6:c.865_867del
NP_005369.2:p.(S289del)
VUS
View →
BRCA2
NM_000059.3:c.3069_3074del
NP_000050.2:p.(N1023_I1024del)
Likely Benign
View →
CDK6
NM_001259.8:c.401A>G
NP_001250.1:p.(D134G)
VUS
View →
PTEN
NM_000314.8:c.388C>G
NP_000305.3:p.(R130G)
Likely Pathogenic
View →
GLA
NM_000169.3:c.937G>T
NP_000160.1:p.(D313Y)
Likely Benign
View →
GNA11
NM_002067.5:c.506_507delinsTT
NP_002058.2:p.(T169I)
VUS
View →
MYC
NM_002467.5:c.517G>A
NP_002458.2:p.(D173N)
VUS
View →
NTRK2
NM_006180.4:c.1529C>A
NP_006171.2:p.(S510*)
Likely Pathogenic
View →
GNA11
NM_002067.5:c.735+1_736-1del
NP_002058.2:p.?
Likely Pathogenic
View →
ABL1
NM_007313.2:c.1001C>T
NP_009297.2:p.(T334I)
Likely Pathogenic
View →
PTPN11
NM_002834.4:c.200G>A
NP_002825.3:p.(G67E)
VUS
View →
SMAD4
NM_005359.5:c.1081C>G
NP_005350.1:p.(R361G)
Pathogenic
View →
PRKD1
NM_002742.3:c.2130A>T
NP_002733.2:p.(E710D)
VUS
View →
NRAS
NM_002524.4:c.34G>T
NP_002515.1:p.(G12C)
Pathogenic
View →
ATM
NM_000051.4:c.2522A>C
NP_000042.3:p.(D841A)
Likely Benign
View →
CHEK2
NM_007194.4:c.1095+19G>A
NP_009125.1:p.?
Likely Benign
View →
SMARCA4
NM_001128849.3:c.3894C>T
NP_001122321.1:p.(D1298=)
Likely Benign
View →
PTCH1
NM_000264.5:c.1641C>T
NP_000255.2:p.(S547=)
Benign
View →
BAP1
NM_004656.4:c.1081_1084del
NP_004647.1:p.(L361Tfs*68)
Likely Pathogenic
View →
CCNE1
NM_001238.4:c.254G>A
NP_001229.1:p.(R85Q)
VUS
View →
PALB2
NM_024675.4:c.3044C>T
NP_078951.2:p.(T1015I)
VUS
View →
JAK1
NM_002227.3:c.1909G>A
NP_002218.2:p.(E637K)
VUS
View →
TP53
NM_000546.6:c.-29+100dup
NP_000537.3:p.?
VUS
View →
CTNNB1
NM_001904.4:c.643G>A
NP_001895.1:p.(A215T)
VUS
View →
PTEN
NM_000314.8:c.844G>T
NP_000305.3:p.(G282*)
Pathogenic
View →
PIK3CA
NM_006218.4:c.2016-11G>A
NP_006209.2:p.?
VUS
View →
DICER1
NM_177438.3:c.5437G>C
NP_803187.1:p.(E1813Q)
VUS
View →
EZHIP
NM_203407.3:c.1272G>A
NP_981952.1:p.(Q424=)
Likely Benign
View →
SMAD4
NM_005359.5:c.1081C>A
NP_005350.1:p.(R361S)
Likely Pathogenic
View →
AR
NM_000044.4:c.2683del
NP_000035.2:p.(M895*)
Likely Pathogenic
View →
FOXL2
NM_023067.4:c.402C>G
NP_075555.1:p.(C134W)
Likely Pathogenic
View →
TERT
NM_198253.2:c.3334C>A
NP_937983.2:p.(L1112M)
VUS
View →
JAK3
NM_000215.3:c.1531A>G
NP_000206.2:p.(M511V)
VUS
View →
NTRK1
NM_002529.3:c.1334G>A
NP_002520.2:p.(R445K)
VUS
View →
KMT2A
NM_005933.3:c.7362T>C
NP_005924.2:p.(T2454=)
Likely Benign
View →
TET2
NM_001127208.2:c.5666C>T
NP_001120680.1:p.(P1889L)
VUS
View →
PRPF8
NM_006445.3:c.5352C>T
NP_006436.3:p.(N1784=)
Likely Benign
View →
TERT
NM_198253.2:c.2781A>G
NP_937983.2:p.(L927=)
VUS
View →
ASXL1
NM_015338.5:c.2694G>A
NP_056153.2:p.(W898*)
VUS
View →
TET2
NM_001127208.2:c.2152del
NP_001120680.1:p.(L718Ffs*33)
Likely Pathogenic
View →
SETBP1
NM_015559.2:c.2953A>G
NP_056374.2:p.(I985V)
VUS
View →
RB1
NM_000321.2:c.345_351del
NP_000312.2:p.(F115Lfs*8)
Likely Pathogenic
View →
FANCD2
NM_033084.4:c.206-1G>A
NP_149075.2:p.?
Likely Pathogenic
View →
ESR1
NM_001122740.1:c.1610A>G
NP_001116212.1:p.(Y537C)
VUS
View →
BRAF
NM_004333.5:c.1661T>C
NP_004324.2:p.(I554T)
VUS
View →
FBXW7
NM_033632.3:c.1697G>T
NP_361014.1:p.(W566L)
VUS
View →
PIK3CA
NM_006218.4:c.2042G>C
NP_006209.2:p.(S681T)
VUS
View →
PSEN1
NM_000021.3:c.1234G>A
NP_000012.1:p.(V412I)
VUS
View →